He is a highly valued figure in the worlds of opera, orchestral, and contemporary music. He currently serves as Chief Conductor and Artistic Director of the Sydney Symphony Orchestra. He served as Music Director of the Saint Louis Symphony Orchestra for 13 years until 2018. He has previously served as Artistic Leader of numerous orchestras, including the Orchestre National de Lyon and Ensemble Intercontemporain. He has frequently appeared with world-renowned opera houses such as the Metropolitan Opera, La Scala, Théâtre du Châtelet, and San Francisco Opera. He has also guest-conducted with world-renowned orchestras in New York, Los Angeles, Boston, Chicago, Philadelphia, Cleveland, Amsterdam, Berlin, and Beijing, and served as Principal Guest Conductor of the BBC Symphony Orchestra. He is also a passionate mentor to young musicians, and since 2018 has been a professor of conducting at the Juilliard School. He has received numerous awards, including the Order of Arts and Letters from the French government in 2011.